Participant consumed grapefruit or grapefruit products within three days ahead of the primary dose of study drug. Ubiquitin-relevant proteins that regulate the stability of key super enhancer-mediated proteins have also been noted to engage in BET inhibitor resistance. As an example, BRD4 interacted with and was de-ubiquitinated by deubiquitinase DUB3. https://abbv-744-clinical-trial-p13568.vblogetin.com/37595566/the-smart-trick-of-abbv-744-preclinical-studies-and-results-that-nobody-is-discussing