Barbiturates may be habit forming. Tolerance and psychological and physical dependence may occur with continuing use. Barbiturates lower serum bilirubin concentrations Per neonates and patients with congenital nonhemolytic unconjugated hyperbilirubinemia, presumably by induction of glucuronyl transferase, the enzyme that conjugates bilirubin. Pentobarbital interacts with several major... https://euthanasiameds.com