Abstract Introduction: The COVID-19 pandemic had an abrupt impact on patient-oriented research early in the pandemic. CTSA Clinical Research Centers (CRCs) rapidly adapted to this challenge. but the continued impact of later phases of the pandemic on CRC operations is not clear. Methods: An online REDCap survey of CTSA CRCs was developed that covered the first 2 years of the pandemic. https://www.chiggate.com/eeboo-memory-matching-game-animal-pre-school-supply/