Analysis into conolidine has brought about discovery of an opioid receptor in the body called ACKR3/CXCR7. ACKR3 is apparently the most wanted target for conolidine, which also disregards one other 4 classical opioid receptors(3). There is interest in utilizing conolidine for a pain-reliever according to evidence from animal study https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers